Extension of a Cox proportional hazards cure model when cure information is partially known
نویسندگان
چکیده
منابع مشابه
Estimation in a Cox proportional hazards cure model.
Some failure time data come from a population that consists of some subjects who are susceptible to and others who are nonsusceptible to the event of interest. The data typically have heavy censoring at the end of the follow-up period, and a standard survival analysis would not always be appropriate. In such situations where there is good scientific or empirical evidence of a nonsusceptible pop...
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The Cox proportional hazards regression model has been widely used in the analysis of survival/duration data. It is semiparametric because the model includes a baseline hazard function that is completely unspecified. We study here the statistical inference of the Cox model where some information about the baseline hazard function is available, but it still remains as an infinite dimensional nui...
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In this paper, we develop a Bayesian approach to estimate a Cox proportional hazards model that allows a threshold in the regression coefficient, when some fraction of subjects are not susceptible to the event of interest. A data augmentation scheme with latent binary cure indicators is adopted to simplify the Markov chain Monte Carlo implementation. Given the binary cure indicators, the Cox cu...
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The proportional hazards curemodel generalizes Cox’s proportional hazardsmodel which allows that a proportion of study subjects may never experience the event of interest. Here nonparametricmaximum likelihood approach is proposed to estimating the cumulative hazard and the regression parameters. The asymptotic properties of the resulting estimators are established using the modern empirical pro...
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As cancer therapy has progressed dramatically, its goal has shifted toward cure of the disease (curative therapy) rather than prolongation of time to death (life-prolonging therapy). Consequently, the proportion of cured patients (c) has become an important measure of the long-term survival benefit derived from therapy. In 1949, Boag addressed this issue by developing the parametric log-normal ...
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ژورنال
عنوان ژورنال: Biostatistics
سال: 2014
ISSN: 1465-4644,1468-4357
DOI: 10.1093/biostatistics/kxu002